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Área de química orgánica

Brieva Collado, M. Rosario

Categoría:
Prof. Titular
Teléfono:
985 102994
Correo:
rbrieva@uniovi.es
Despacho:
253-3
Ficha personal:
Ficha personal de la Universidad de Oviedo
Web personal:
Página web personal

Áreas de interés:

  • Síntesis orgánica
  • Biocatálisis
  • Síntesis de fármacos y moléculas de interés terapeutico.

Publicaciones:

  • "Enzymatic aminolysis and transamidation reaction" V. Gotor, R. Brieva, C. González, F. Rebolledo. Tetrahedron, 1991, 47, 9207-9214. : Enlace
  • "Biocatalytic methods for enantioselective synthesis" J. Sih, R. L.Gu, J. Z. Crich, R.Brieva. In "Stereocontroled Organic Synthesis", ed. B. M. Trost, I.U.P.A.C. 1994, 399-411.
  • "Enzymatic resolution of trans-4-(4'-fluorophenyl)-3-hydroxymethylpiperidines, key intermediates in the synthesis of (–)-Paroxetine." G. de Gonzalo, R. Brieva, V. M. Sánchez, M. Bayod, V. Gotor Journal of Organic Chemistry, 2001, 66, 8947-8953 : Enlace
  • "Optically active (S)-ketone and (R)-aldehyde-cyanohydrins via an (R)-oxynitrilase-catalysed transcianation. Chemoenzymatic synthesis of 2-cyanotetrahydrofuran and 2-cyanotetrahydropyran" E. Menéndez, R. Brieva, F. Rebolledo, V. Gotor. J. Chem. Soc., Chem. Commun., 1995, 989-990. : Enlace
  • "Lipases: useful biocatalysts for the preparation of pharmaceuticals". V. Gotor-Fernández, R. Brieva, V. Gotor. Journal of Molecular Catalysis B: Enzymatic, 2006, 111-120. : Enlace
  • "Enzymatic resolution of hindered cyanohydrins, key precursors of muscarinic receptor antagonists". V. Recuero, M. Ferrero, V. Gotor-Fernández, R. Brieva, V. Gotor. Tetrahedron: Asymmetry, 2007, 18, 994-1002 : Enlace
  • "Combination of Biocatalysis and Chemical Catalysis for the Preparation of Pharmaceuticals through Multi-Step Syntheses". V. Gotor-Fernández, R. Brieva, V. Gotor. Multi-Step Enzyme Catalysis: Biotransformations and Chemoenzymatic Synthesis. Wiley-VCH, 2008, Weinheim (Germany). Capítulo 10. Pags 213-233.
  • "Biocatalytic preparation of chiral 3,4-dihydroxypyrrolidines". Jesús A. Rodríguez-Rodríguez, R. Brieva, V. Gotor. Tetrahedron, 2010, 66, 6789-6796 :
  • "Lipase catalyzed resolution of the quaternary stereogenic center in ketone-derived benzo-fused cyclic cyanohydrins". Jesús A. Rodríguez-Rodríguez, V. Gotor, R. Brieva. Tetrahedron Asymmetry, 2011, 22, 1218-1224 : Enlace
  • "Chemoenzymatic synthesis of orthogonally protected (3R,4R)- and (3S,4S)-trans-3-amino-4-hydroxypyrrolidines" Tetrahedron, 2013, 26, 5407-5412. : Enlace